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May 1959

Kernicterus in Rats with an Inherited Deficiency of Glucuronyl Transferase

Author Affiliations

New York
From the Department of Pediatrics of the State University of New York, Downstate Medical Center, and the Department of Pathology, College of Physicians and Surgeons, Columbia University.

AMA Am J Dis Child. 1959;97(5_PART_I):591-608. doi:10.1001/archpedi.1959.02070010593009

This paper describes the occurrence of kernicterus and factors which influence its development in the strain of rats * first studied by Gunn.22,23 The disease of humans designated in 1903 by Schmorl39 as kernicterus has, in our opinion, not been observed or induced in its entirety in animals. Various workers, however, have demonstrated the toxicity of indirect bilirubin.12-15,24,26,44-46 Ernster, Herlin, and Zetterström21 have caused localized pigmentation of the brain of the rabbit by treatment with bilirubin and an S-H blocking agent. Other workers17,19,20 have reported injury of brain tissue in hemolytic anemia of animals, a phenomenon not directly related to the present report, since the rats to be described do not suffer from antibody-antigen disease and have little or no hemolytic

Definition of Kernicterus  The following criteria are proposed as defining kernicterus:

  1. Distinctive evidence of central nervous system dysfunction during life in jaundiced subjects

  1. Canary yellow

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