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May 1959

The Partition of Tissue Phospholipides by Phosphorus Analysis

Author Affiliations

From the Research Laboratories of the Boston Dispensary and Department of Biochemistry, Tufts University School of Medicine.

AMA Am J Dis Child. 1959;97(5_PART_II):691-708. doi:10.1001/archpedi.1959.02070010693007

The known tissue phospholipides may be divided into four different groups on the basis of the nature of certain bonds between the lipide groups and between the phosphorus-containing groups of their molecules: 1. Ester phospholipides such as lecithin (phosphatidyl choline), certain cephalins such as inositol cephalin, phosphatidyl ethanolamine, and phosphatidyl serin. Their lipide groups are exclusively fatty acids which are linked to the phosphorus-containing moiety of each molecule by alkali-labile ester bonds. 2. Plasmalogens. Each molecule of this group contains as lipide groups an aldehydogenic group and a fatty acid group. The former appears to be attached to the phosphorus-containing moiety in the form of a vinyl ether (dehydrated hemi-acetal)* by a linkage which is very labile towards acids and mercury2 ions, the latter by an alkali-labile ester linkage.1,13,14 3. Etherphospholipides3 which contain as lipide groups long-chain alcohol groups which are attached to the phosphorus-containing part