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August 1959

Observations on a Baby Born to a Mother with Congenital Adrenal Hyperplasia

Author Affiliations

Petah Tikva, Israel
Department of Pediatrics and the Medical Research Institue of the Labour Sick Fund, Beilinson Hospital, Petah Tikva, Israel.

AMA Am J Dis Child. 1959;98(2):162-165. doi:10.1001/archpedi.1959.02070020164004

Since the introduction of cortisone as treatment of the adrenogenital syndrome by Wilkins et al.1 only three women with congenital adrenal hyperplasia, including one from this hospital, have been reported to have given birth to a live baby.2-4

Considering the problems presented by the baby of a mother with the adrenogenital syndrome, a disease generally considered inheritable,5 and in particular the possible damage to the fetus by prolonged administration of cortisone to the pregnant mother, it seems justified to present the metabolic and endocrine studies performed on such a baby born in our hospital.

Report of Case  The patient's mother came under medical attention at the age of 16 years, because of hirsutism and amenorrhea, and was found to have a very enlarged clitoris and a urogenital sinus. She had had pubic and axillary hair since the age of 3 years. She was considered to have female

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