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August 1959

Lamellar Exfoliation of the Newborn, or Ichthyosis Congenita

Author Affiliations

Instructor in the Department of Dermatology, University of Minnesota School of Medicine (Dr. Smith).

AMA Am J Dis Child. 1959;98(2):249-252. doi:10.1001/archpedi.1959.02070020251011

A baby who was born with a collodion-like membrane over the entire body has recently been under our observation. We used the term "lamellar exfoliation of the newborn" introduced by Grass and Török1 but observed the baby for two years before establishing a final diagnosis. The actual significance of this term is not clear, nor is its use universally accepted. Shelmire Jr.2 recently reviewed the literature and found 15 cases of this entity. He proposed preservation of the term lamellar exfoliation of the newborn as descriptive of a distinct entity and suggested that the frequent association of this defect with ichthyosis is but another example of multiple congenital ectodermal defects. He noted, however, that even in the mildest cases there was usually residual dryness and desquamation of the skin. In reviewing the literature on this subject,3-5 we found only one instance in which the skin was described

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