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September 1959

Testosterone-Induced Remission in Aplastic Anemia

Author Affiliations

Research Fellow in Medicine, Children's Medical Center, and Research Fellow in Pediatrics, Harvard Medical School (Dr. Shahidi). Associate Chief, Medical Service, Children's Hospital, and Associate Professor of Pediatrics, Harvard Medical School (Dr. Diamond).

AMA Am J Dis Child. 1959;98(3):293-302. doi:10.1001/archpedi.1959.02070020295002

Introduction  The treatment of aplastic anemia in childhood and adolescence has been one of the most hopeless and discouraging problems in the practice of pediatrics. In addition it has become a very worrisome problem since it seems to us that its incidence is increasing steadily. Review of the cases of aplastic anemia seen at the Children's Hospital during the past 20 years revealed that of 40 patients only 2 had a spontaneous remission and only one survived after four years. The others died from either generalized infection or hemorrhage. All therapeutic efforts have been uniformly unsuccessful. Transfusions, vitamin preparations, splenectomy, corticosteroids, and corticotropin have been tried singly or in combination, to no avail.The aim of this paper is to describe a new approach to the therapy of this serious disease. For the past 16 months in addition to corticosteroid therapy and transfusion of platelets, fresh blood, and stored blood

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