A good laboratory test, which can help establish the diagnosis and evaluate the activity of tuberculous disease, would be of inestimable value in the management of the tuberculous patient. With the advent of antimicrobial therapy, we need the additional service of an indicator to help the clinician decide when to treat and for how long. Ideally, one would strive for a test which is specific for the disease. Unfortunately, this ideal still eludes us. The hemagglutination test,1 which appeared to hold such great promise initially, has been scrutinized again, recently, by Hirsch and associates,2 in a group of patients followed with meticulous care. This study confirmed previous observations that there was no correlation between activity of tuberculous disease and hemagglutination titers.
In lieu of specific tests, then, can we get the required information from other sources? There have been several studies on the change of the serum γ-globulin
ZITRIN CM, LINCOLN EM, CARRETERO R, MELLY E. Serum Proteins in Childhood Tuberculosis. AMA Am J Dis Child. 1959;98(3):330–341. doi:10.1001/archpedi.1959.02070020332006
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