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September 1959

Neonatal Hepatitis

Author Affiliations

Rochester, Minn.
Fellow in Pathology, Mayo Foundation (Dr. Shorter); Section of Pathologic Anatomy (Dr. Baggenstoss) and Section of Pediatrics (Dr. Logan), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Am J Dis Child. 1959;98(3):359-369. doi:10.1001/archpedi.1959.02070020361010

The presence of jaundice at birth or its onset early in the neonatal period may present formidable diagnostic difficulties to the pediatrician and to the pathologist, especially if the jaundice is prolonged and of the regurgitant form. If erythroblastosis fetalis is excluded, the differential diagnosis in most instances lies between congenital atresia of the bile ducts and neonatal (giant cell) hepatitis. Both these conditions have been the subject of studies in the literature,1-15 and it is apparent that many clinical and biochemical similarities exist between the two conditions. As a result, exploratory laparotomy is commonly undertaken in such cases to assess the patency of the biliary tree, and wedges of tissue resected from the liver are supplied to the pathologist for histologic examination.

Since congenital atresia of the bile ducts and neonatal hepatitis are rare in clinical and pathologic practice, the purpose of this communication is to review the

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