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December 1959

Bromide Space in Infants and Children

Author Affiliations

Birmingham, Ala.
Departments of Pediatrics and Pharmacology, Medical College of Alabama.

AMA Am J Dis Child. 1959;98(6):749-755. doi:10.1001/archpedi.1959.02070020751010

Introduction  It is well established that when bromide is administered to a human or animal subject it exchanges rapidly with nearly all of the body chloride.1-6 For this reason the volume of distribution of bromide is essentially the same as that of chloride, the exception being the cerebrospinal fluid. When bromide volume of distribution is multiplied by the chloride concentration in serum, the quantity of chloride obtained is that which exchanges rapidly with bromide, and may therefore be called "exchangeable chloride," although it is sometimes called "total body chloride" since the values are so nearly the same.6-7Since the volume of distribution of chloride includes the extracellular fluid, connective tissue, skin, erythrocytes, and, to a minor extent, some other cells, the relationship between chloride (or bromide) space and total body mass will depend upon the composition of the body. When a large proportion of the body weight is

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