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December 1959

Two Cases of Salicylate Intoxication Successfully Treated by Exchange Transfusion

Author Affiliations

Glastonbury, Conn.; Hartford, Conn.

AMA Am J Dis Child. 1959;98(6):778-785. doi:10.1001/archpedi.1959.02070020780015

In the past few years, the artificial kidney and exchange transfusion have been advised for removal of excessive salicylate from the body. Two cases of salicylate poisoning treated successfully by exchange transfusion are presented to show that this technique is practical and effective. A brief review of the literature is included with special emphasis on the role of hemodialysis or exchange transfusion in the treatment of salicylate and other exogenous intoxications.

Incidence of Intoxication  Summaries published by various poison control centers throughout the United States have indicated that acetylsalicylic acid is responsible for more poison cases treated in hospital emergency rooms than any other single substance.1 A recent one-year survey of accidental poisoning in Connecticut showed that out of 322 poison cases, 33% involved acetylsalicylic acid.2 Of 486 accidental poisonings treated in the emergency clinic of the Children's Medical Center in Boston in the two-year period 1956-1957, 146 (30%)

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