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January 1960

Human Growth Hormone: I. Metabolic Balance Studies Carried Out in a Hypopituitary Child

Author Affiliations

Department of Pediatrics, University of Washington School of Medicine (Dr. Shepard and Miss Bernstein); School of Home Economics, University of Washington (Dr. Johnson), and Mason Clinic (Dr. Nielsen).

AMA Am J Dis Child. 1960;99(1):74-80. doi:10.1001/archpedi.1960.02070030076013

Introduction  Although there are numerous brief reports concerning the metabolic effectiveness of human growth hormone,1-8 the full details of a metabolic balance study in a young child have not been published. It is the purpose of this paper to report detailed results of a metabolic balance study carried out on a 3 10/12-year-old "hypopituitary" boy. To define what is meant by "hypopituitary" a case report describing the subject is included. The human growth hormone employed was obtained from Dr. Maurice Raben9 and was administered intramuscularly in a dosage of 5 mg. per day.

Report of Case  The patient was a 310/12-year-old Japanese boy, referred because of gradual deceleration in linear growth.* At birth, his weight was 3,200 gm. and his length was 47 cm. The pregnancy was uncomplicated, but the delivery was notable in that a precipitous delivery was necessitated by a prolapse of the umbilical cord. There

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