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February 1960

Hypogammaglobulinemia in Systemic Lupus Erythematosus: Report of a Case in a Nine-Year-Old Child

Author Affiliations

Beth-El Hospital (Dr. Weinstock).

AMA Am J Dis Child. 1960;99(2):242-247. doi:10.1001/archpedi.1960.02070030244017

Systemic lupus erythematosus (S.L.E.) is associated with striking plasma protein changes, among which hypergammaglobulinemia is usually prominent. The purpose of reporting this case in detail is to call attention to a patient with S.L.E. associated with the rare feature of a chronically low concentration of γ-globulin. This is unique because, to the best of our knowledge, this is the first case of S.L.E. with hypogammaglobulinemia in the pediatric age group to be recorded in detail.

In this report an opportunity was afforded to study the survival time of intramuscularly injected γ-globulin.

This case also presented the opportunity to observe the effects of continuous corticosteroid therapy for three years and intramuscularly injected γ-globulin over a period of two years.

Report of Case  On May 4, 1956, this 9-year-old white girl with anorexia, low-grade fever of six weeks' duration, and a pruritic erythematous facial rash of four days' duration was admitted to

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