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April 1960

Primary Endocardial Fibroelastosis in Two Sisters

Author Affiliations

Haifa, Israel
From the Departments of Pediatrics and Pathology, Rothschild Municipal Hospital.; Department of Pediatrics, Rothschild Municipal Hospital.

AMA Am J Dis Child. 1960;99(4):529-533. doi:10.1001/archpedi.1960.02070030531016

Endocardial fibroelastosis was first reported by Kreysig, in 1816, under the misnomer of fetal endocarditis.1 New concepts have developed in the understanding of this condition, especially since 1941. This term is now generally accepted as embracing various entities, including adult forms. Andersen and Kelly,2 in 1956, showed that many children with congenital heart disease develop endocardial fibroelastosis, apparently secondary to hemodynamic factors or anoxia in the malformed heart. A single group remains unassociated with other cardiac abnormalities, and this is termed "primary" endocardial fibroelastosis.3 The etiology of primary endocardial fibroelastosis is not certain, but it has been suggested that this lesion is a genetically determined developmental anomaly, possibly due to an enzymatic defect of the myocardium.1 The occurrence of primary endocardial fibroelastosis in siblings is rare. An accumulation of data on such familial cases might support the theory of a familial metabolic disorder, as well as

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