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May 1960

A Clinical Evaluation of Four Oxyuricides

Author Affiliations

Department of Pediatrics, School of Medicine, University of Buffalo, and Edward J. Meyer Memorial Hospital.; Associate Clinical Professor of Pediatrics (Dr. Bumbalo); Associate in Pediatrics (Dr. Plummer); Assistant in Pediatrics (Dr. Warner), University of Buffalo School of Medicine.

AMA Am J Dis Child. 1960;99(5):617-621. doi:10.1001/archpedi.1960.02070030619007

In recent years, attention has been focused on the increased incidence of parasitic diseases in the United States.1,2 Enterobiasis (infection by the pinworm Enterobius vermicularis) is still a common and troublesome pediatric problem, even though many investigators have reported a variety of successful treatments of this parasitic infection.3-6

Simplification of treatment regimens can contribute immeasurably to a decrease in the incidence and a better control of this infection. To date, in a variety of regimens, we have evaluated the following drugs in the treatment of pinworm infection in children: Egressin (thymol-n-isoamylcarbamate), Diphenan (parabenzlphenylcarbamate), methylrosaniline chloride (gentian violet), oxytetracycline, papain, Cremothalidine, (a phthalylsulfathiazole preparation), carbomycin, garlic, piperazine, promethazine hydrochloride, pyrathiazine, and pyrvinium chloride.5,7-10

In a more recent study (5) we reported the results of treatment of 139 children infected with pinworms. Thirty-four children, varying in age and weight, were treated with a single dose of 3

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