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July 1960

Antipyretic Activity of Acetylsalicylic Acid and Salicylamide Suspension in Pediatrics: A Comparative Clinical Evaluation in Two Hundred Six Cases

Author Affiliations

Professor and Chairman, Department of Pediatrics, Chicago Medical School; Attending Pediatrician, Cook County Children's, Mount Sinai, and Columbus Hospitals.

Am J Dis Child. 1960;100(1):23-30. doi:10.1001/archpedi.1960.04020040025007

Since the recent introduction of liquid suspension preparations of salicylamide, there has been some controversy about their efficacy as antipyretics. Although acetylsalicylic acid (aspirin) is available in palatable forms, it is difficult to prepare it in a liquid state, or to maintain the stability in solution. The correction of the febrile state of the patient and patient comfort are paramount responsibilities of a physician. Consequently, the question of whether salicylamide may replace acetylsalicylic acid as an antipyretic is very important, particularly in pediatrics. The further claims made as to the relative safety of the different preparations involved also require further elucidation.

Background  Over the years acetylsalicylic acid has proved to be one of the most reliable weapons in the physicians' armamentarium.It has been among the most valuable and frequently used pharmacotherapeutic agents throughout the range of medicine. Among other things, it is the basic analgesic against aches and pains,

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