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December 1960

Aldrich's Syndrome (Thrombocytopenia, Eczema, and Recurrent Infections): Report of a Case

Author Affiliations

Athens, Greece
Pediatric Clinic, University of Athens (Dr. Cassimos).; From the Department of Pediatrics, University of Athens (Professor and Chairman of Pediatrics Dr. K. B. Choremis).; Ass. Professor in Pediatrics (Dr. Cassimos), Instructor in Pediatrics (Dr. Anastasea-Vlahou), Senior Resident in Pediatrics (Dr. Kattamis, Dr. Kanavakis), University of Athens.

Am J Dis Child. 1960;100(6):914-917. doi:10.1001/archpedi.1960.04020040916017

The term Aldrich's syndrome was given by Krivit and Good4 to a condition characterized by thrombocytopenia, eczema, and recurrent infections in infancy and childhood. This clinical entity was first described in a family by Aldrich, Steinberg, and Campbell1 in 1954. Later Huntely and Dees,3 and Wolff and Bertucio,5 reported 11 additional cases of infants and children who died from the same disease, while Cummins and co-workers2 described the syndrome in twins who are still alive. Krivit and Good4 carried out extensive immunohematological and endocrinological investigations on seven other cases. Despite these studies the etiology of the syndrome still remains unknown.

Here, we present another case of this interesting syndrome.

Report of Case  A 4-month-old male infant was admitted to the Childrens Hospital of Athens University on March 15, 1959, because of fever, vomiting, and bloody diarrhea. At the age of 45 days he had

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