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January 1961

Familial Mediterranean Fever: Report of Four Cases

Author Affiliations

Department of Pediatrics, University of Colorado School of Medicine.; From the University of California at Los Angeles School of Medicine.; From the University of California at Los Angeles School of Medicine.

Am J Dis Child. 1961;101(1):52-59. doi:10.1001/archpedi.1961.04020020054009

Introduction  Familial Mediterranean fever is a disease entity consisting of chronic, recurrent episodes of fever and pain—abdominal, thoracic, or joint pain, occurring either singly or in various combinations. A similar clinical entity has been widely recorded in the medical literature under various names. In 1908, Janeway and Mosenthal1 reported recurrent attacks of abdominal pain in a 16-year-old Jewish girl as "An Unusual Paroxysmal Syndrome." Subsequently the disease has been referred to as benign paroxysmal peritonitis (Siegal, 19455); periodic abdominalgia, periodic peritonitis (Reimann, 1949, 19547,8); la maladie périodique (Mamou and Cattan, 195211); familial Mediterranean fever (Heller, Sohar, and Sherf, 195717; Lawrence and Mellinkoff, 195919); familial recurring polyserositis (Priest and Nixon, 195920), and the "Armenian Disease." The literature contains reports of syndromes resembling familial Mediterranean fever as examples of gastrointestinal allergy, Henoch's purpura, and abdominal epilepsy.The disease is familiar to the internists but prior

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