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February 1961

Duodenal Ulceration and Fibrocystic Pancreas Disease

Author Affiliations

From the Department of Pathology, Dalhousie University, and the Children's Hospital.

Am J Dis Child. 1961;101(2):210-215. doi:10.1001/archpedi.1961.04020030074012

Although cystic fibrosis of the pancreas is now one of the most widely studied diseases of childhood, the association of this disease with ulceration of the duodenum has only infrequently been reported. On theoretical grounds, such an association would, however, be expected, since the development of ulcers of the duodenum following the diversion of pancreatic juice from this part of the intestine has been clearly demonstrated in the experimental animal by such early observers as Mann and Williamson,1 Elman,2 and Dragstedt.3

More recently, Poth and Fromm4 have similarly implicated the deficient neutralization of acid in the duodenum because of pancreatic insufficiency as a factor in the causation of peptic ulceration. It may be of interest in this connection to draw attention to the findings of Shwachman and Leubner5 who noted that, in a large proportion of cases of cystic fibrosis of the pancreas studied by