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April 1961

Triacetyloleandomycin—a Substitute for Penicillin G: A Comparison of the Therapeutic Effectiveness of Triacetyloleandomycin, Erythromycin Propionate, and Oral Penicillin G in the Treatment of Beta Hemolytic Streptococcal Infections

Author Affiliations

From the Department of Pediatrics, University of Rochester School of Medicine and Dentistry.; Dr. Edward Roberts of Wyeth Laboratories first suggested that triacetyloleandomycin and erythromycin propionate might be compared clinically in β-hemolytic streptococcal infections. He and Dr. R. S. Griffith of Eli Lilly were both helpful in supplying references and data on the drugs tested.

Am J Dis Child. 1961;101(4):423-428. doi:10.1001/archpedi.1961.04020050013004

In this paper we wish to report for the first time observations which indicate that, in the treatment of βhemolytic streptococcal infections in children, triacetyloleandomycin (Cyclamycin) is an excellent substitute for penicillin and superior to erythromycin propionate (Ilosone).

Although penicillin has been considered the drug of choice against these organisms1 (and still is in our opinion), we should examine new agents to determine if they may be either more effective for general use or at least equally effective for patients allergic to penicillin. In this search for effective substitutes for penicillin 2 promising new preparations of erythromycin and oleandomycin were subjected to a controlled clinical trial in the treatment of these infections in children. They were erythromycin propionate (Ilosone) and triacetyloleandomycin (Cyclamycin). These 2 new antibiotic agents had, in in vitro tests, been shown to be effective against the β-hemolytic streptococcus, and, in the sera of volunteers, to give

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