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April 1961

Hyperglobulinemia Secondary to Massive Lymphangioma

Author Affiliations

The Children's Hospital, Elland and Bethesda Aves. (29) (Dr. Landing).; From the Divisions of Pediatrics, Surgery, Pathology, and Biochemistry of The Children's Hospital and Children's Hospital Research Foundation, Cincinnati, and the University of Cincinnati College of Medicine.

Am J Dis Child. 1961;101(4):510-513. doi:10.1001/archpedi.1961.04020050100015

Introduction  The association of hyperglobulinemia with large lymphangiomas or with extensive lymphangiectasia, as in Milroy's disease, has been recorded, but to our knowledge, no studies on the nature of this association have been published. "Sequestration" of blood platelets by hemangiomas with resultant thrombocytopenic purpura, anemia due to chronic blood loss from ulcerated superficial hemangiomas, and protein depletion due to gastrointestinal lymphatic obstruction by mesenteric lymphangioma represent additional examples of system effects of angiomas. The present paper describes studies on an infant with hyperglobulinemia and a large cavernous lymphangioma and discusses the possible causes of the phenomenon.

Report of a Case  A white female infant, born Feb. 26, 1957, was first admitted to the Cincinnati Children's Hospital on Aug. 31, 1958. At birth, she was found to have massive lymphangiomatosis of the right foot, leg, and buttock (Fig. 1). During infancy there were episodes of infection of the affected leg, but

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