Erythema multiforme exudativum Stevens-Johnson syndrome) has been described in association with the administration of numerous medications, including sulfonamides,1-6 penicillin,7 thiouracil,5 phenylbutazone,8 salicylates, codeine,9 Fowler's solution,10 phenolphthalein,7 barbiturates,11,12 trimethadione,13 and diphenylhydantoin.14-16 A reversible, lupus-like disease, characterized by the L.E. cell phenomenon, with or without renal and systemic involvement, has also been attributed to medications such as hydralazine,17-22 penicillin,23,24 phenylbutazone,17 sulfadiazine,25,26 and methylphenylethylhydantoin (Mesantoin).27
It is the purpose of this paper to report the simultaneous occurrence of erythema multiforme exudativum and a reversible, lupus-erythematosus-like disease in 2 adolescent girls, as well as acute lupus erythematosus alone in a 4-year-old boy, following medication with anticonvulsant drugs.
Report of Cases
Case 1.—At the age of 7½ years, this girl began experiencing petit mal seizures characterized by momentary lapses of consciousness, substantiated by typical 3-per-second spike and wave discharges on the electroencephalogram. She was given trimethadione (Tridione), 900 mg. daily, and phenobarbital, 45 mg.
RALLISON ML, CARLISLE JW, LEE RE, VERNIER RL, GOOD RA. Lupus Erythematosus and Stevens-Johnson Syndrome: Occurrence as Reactions to Anticonvulsant Medication. Am J Dis Child. 1961;101(6):725–738. doi:10.1001/archpedi.1961.04020070039007
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