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July 1961

Influence of Dietary Fatty Acids on Serum Lipids: Studies of the Immature Rhesus Monkey (Macaca Mulatta)

Author Affiliations

Dr. Pickering, Department of Pediatrics, University of Oregon Medical School, 3181 S. W. Sam Jackson Park Rd. (1).; From the Primate Laboratories of the Departments of Pediatrics and Biochemistry, University of Oregon Medical School.

Am J Dis Child. 1961;102(1):42-51. doi:10.1001/archpedi.1961.02080010044009

Recent investigations suggest a relationship between atherosclerotic vascular disease in man, elevations of certain lipid constituents in the serum, and the total amount and nature of the fat in the diet.1-17

Atherosclerotic vascular disease, while not uncommon in the young adult, is uncommon in children; however, underlying degenerative changes similar to those seen in the prelipid lesions of adults are regularly observed in infancy and early childhood.18-23

The effect of certain diets with qualitative differences in fatty acid composition upon growth and development, serum lipids, and cardiovascular pathology has been studied in mulatta macaque monkeys through the first year of life.

Materials and Methods  Animals used in these investigations were the products of carefully documented pregnancies, maintained and delivered according to the standard procedures of this laboratory.24 All animals were born at gestational age 168 ±4 days. Each infant was assigned to 1 of 2 dietary groups.

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