The goitrogenic effect of soybean diets in animals has been recognized for some 25 years.1 The fact that these effects can be modified by heat, organic solvent extraction, or the addition of iodine4,5 suggested that a specific goitrogenic substance was present in soybeans. Until recently, only one case of goiter in an infant had been reported.6 In a recent comprehensive article, Van Wyck et al.7 described a 10-month-old female infant who was observed and studied after having developed a goiter and mild hypothyroidism while on a soybean milk product. Their studies suggested that a goitrogenic agent which interfered with hormonal synthesis in certain susceptible individuals was present in soybeans. Hydovitz8 discussed the appearance of thyroid enlargement in a 4½-month-old male infant maintained on a soybean extract and the subsequent disappearance of the enlargement after the elimination of this nutrient. Shepard et al.9 reported 3
RIPP JA. Soybean-Induced Goiter. Am J Dis Child. 1961;102(1):106–109. doi:10.1001/archpedi.1961.02080010108017
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