The studies, The Essential Amino Acid Requirements of Infants, by Synderman et al.1,2 may seem of remote value in the "practical" everyday feeding of infants. Yet these studies, and numerous similar ones by others, are significant contributions to the science of nutrition.
Holt et al.3 have demonstrated "under the conditions" of their studies that histidine is an indispensable amino acid for the young infant and that arginine is not—in contrast to the findings for adults.
From quantitative measurements of the concentration of each amino acid in the plasma during short periods of deficiency of a single amino acid, unexpected plasma concentration variations have been found. These clues will stimulate further investigation of the inter-relationships of the metabolism of individual amino acids, lead to clarification of the concept of "amino acid imbalance," and hasten the elucidation of additional metabolic disorders analogous to phenylketonuria and maple syrup disease.
PRATT EL. Essential Dietary Amino Acids: Guest Editorial. Am J Dis Child. 1961;102(2):155–156. doi:10.1001/archpedi.1961.02080010157001
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