[Skip to Navigation]
August 1961

Spontaneous Involution of Giant Hemangioma: Simultaneous Regression of Tumor and Thrombocytopenia in Newborn

Author Affiliations

Children's Hospital, Hematology Research Laboratory.; R. O. Wallerstein, M.D., 2000 Van Ness Ave., San Francisco 9.

Am J Dis Child. 1961;102(2):233-235. doi:10.1001/archpedi.1961.02080010235014

Association of hemangioendothelioma with thrombocytopenic purpura has been described repeatedly.1,2 The tumor is usually obvious at birth. Radiation therapy has been thought to be of value; surgical removal of the tumor has been performed3; splenectomy is apparently not beneficial. As the tumor shrinks, purpura ceases, and platelet counts return to normal. There are a few reports of spontaneous involution of cavernous hemangioma.4 The interest in the following case revolves about the spontaneous regression of a huge hemangioma with thrombocytopenic purpura in the first 6 months of life.

Case History  The patient, a boy, was admitted to Children's Hospital, at the age of 3 days, because of jaundice, hematemesis, and a large tumor on the left leg. He was born of a full-term pregnancy; normal delivery. His birth weight was 3175 gm. (7 lb.); there was no neonatal distress. Jaundice was noticed at 12 hours. The patient vomited

Add or change institution