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September 1961

Growth Status of Children with Sickle-Cell Anemia

Am J Dis Child. 1961;102(3):355-364. doi:10.1001/archpedi.1961.02080010357009

Although it is generally accepted that sickle-cell anemia has an adverse effect upon physical growth, published data on this aspect of the disease in children are meager. Scott et al.1 reported that the weights of 63 children with sickle-cell anemia were consistently below the median for their age. Winsor and Burch,2 in a detailed evaluation of the physical habitus of persons with sickle-cell anemia, included physical measurements on 7 children. They found that the weights of all the children and the heights of the 4 girls were subnormal.

This study was undertaken to provide additional data on the growth and maturation status of children with this disease, and to evaluate some of the factors which may contribute to growth retardation when it occurs.

Materials and Methods  The primary subjects were 48 American Negro children with sickle-cell anemia, ranging from 2-13 years of age. The diagnosis was established by

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