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September 1961

Pancytopenia with Hyperplastic Marrow: A Case with Multiple Congenital Anomalies Responding to Testosterone

Author Affiliations

John H. Githens, M.D., Department of Pediatrics, University of Colorado Medical Center, 4200 E. Ninth Ave. (20).; From the Department of Pediatrics, University of Colorado Medical Center.

Am J Dis Child. 1961;102(3):389-394. doi:10.1001/archpedi.1961.02080010391016

The purpose of this paper is to report a patient with pancytopenia in the presence of hyperplastic bone marrow with a maturation arrest of the erythrocytic and granulocytic elements, and in whom treatment with testosterone was associated with a complete remission of her pancytopenia. She also exhibited multiple congenital anomalies of the type described in cases of "Fanconi's hypoplastic anemia."1-2

Report of Case  The patient was a Caucasian girl, first seen in April, 1954, at the age of 11 years, with the history of frequent spontaneous epistaxis, easy bruising, and increasing fatigability for a period of several years. Unfortunately, the exact age of onset of symptoms was not available; however, the patient apparently had her first severe nose bleed at age 7 years according to institution records. She was a ward of the state, and details of gestation, birth, and early development were unavailable. The patient had had chickenpox,

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