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December 1961

Aseptic Meningitis Syndrome Due to Virus Echo Type 23

Author Affiliations

D. N. Walcher, M.D., Dept. of Pediatrics, Indiana University Medical Center, 1100 W. Michigan Ave., Indianapolis 7.; International Cooperation Administration Fellow (Dr. Jhala); Research Assistant, Pediatric Communicable Disease Laboratories (Janet Draper); Associate Professor of Pediatrics (Dr. Walcher).

Am J Dis Child. 1961;102(6):868-870. doi:10.1001/archpedi.1961.02080010870010

Aseptic meningitis, described and defined by Wallgren,1 in 1924, is a syndrome with diverse etiologies. Clinical and etiologic studies were carried out on 854 cases of aseptic meningitis by Adair et al.,2 in 1953. They observed that about 25% of the cases could be associated with a viral etiology, 9.2% of which were positive for lymphocytic choriomeningitis, 12.3% for mumps, and 1.2% for herpes simplex. Progress in our understanding of the etiology of aseptic meningitis has come from the recently acquired knowledge relating to the enterovirus groups which now have been recognized to cause a high percentage of the cases of aseptic meningitis. This is evident from a report by Meyer et al.,3 who studied 430 patients with aseptic meningitis; specific etiology was established in 305 of their cases, 54% being enteroviruses.

In addition to the 3 polio viruses, Coxsackie A Types 1, 2, 4-7, 9, 10,

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