Since central nervous system involvement in infectious mononucleosis was first suggested by Longcope, in 1922,1 this complication has been quite uncommon.2-4 The usual reported incidence of central nervous system complications is 1% or less.1,5 Thomsen reported 9% of cases with clinical symptoms or pleocytosis of the spinal fluid.6 Central nervous system involvement is more common in males than females,1,5 adults than children,1,5,7,8 and rarely affects Negroes.1,9 Symptoms usually have their onset 1 to 3 weeks after the onset of the disease5 and often there is a short symptom-free interval between the appearance of the typical symptoms of the disease and the neurologic complications.10 While it is by no means the rule, several observers have pointed out that the usual clinical picture of infectious mononucleosis may be totally lacking in cases involving the central nervous system.1,24 Symptoms vary widely and may
NICHOLS WW, ATHREYA B. Encephalitis Probably Due to Infectious Mononucleosis: Report of Four Cases. Am J Dis Child. 1962;103(1):72–76. doi:10.1001/archpedi.1962.02080020076012
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