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March 1962

Vaccination with Attenuated Measles-Virus Vaccine: Clinical and Immunological Studies

Author Affiliations

P. Halonen, M.D., Virus Laboratory, University of Helsinki, Helsinki, Finland.; From the Department of Virology, University of Helsinki, and the Children's Institution Folkhälsan.

Am J Dis Child. 1962;103(3):347-350. doi:10.1001/archpedi.1962.02080020359033

The immunological efficacy and the absence of communicability of live attenuated measles-virus vaccine in children has been described by Katz and Enders1 and by others2-10 Since immunity to natural measles infection shortly after vaccination has also been reported,3,4 the final acceptance of this vaccine for routine pediatric immunization will presumably depend on the persistence of the immunity conferred and on the severity of reactions to the vaccination.

The main purpose of the study undertaken here has been to gain further information regarding the reactions caused by a subcutaneously inoculated attenuated measles-virus vaccine prepared from the chick-embryo-adapted Edmonston strain in institutionalized children and the effect of γ-globulin on such reactions. In addition, the serological response to vaccination was tested by complement fixation (CF) and hemagglutination inhibition (HI) techniques. The full report of this study will be published elsewhere.11

Material and Methods  Design and Operation of Study.—The

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