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March 1962

Further Experiences with Live Measles Vaccines in U.S.S.R.Use of Virus Propagated in Chick Fibroblasts and in Guinea Pig Kidney Cells

Author Affiliations

A. A. Smorodintsev, M.D., Leningrad Pasteur Institute of Epidemiology and Microbiology, Leningrad, U.S.S.R.; Leningrad Pasteur Institute of Epidemiology and Microbiology (Drs. A. Smorodintsev, L. Boychuk, E. Shikina, T. Peradze); Leningrad Pediatric Institute (Drs. A. Kuzmicheva, L. Bystryakova, T. Batanova).

Am J Dis Child. 1962;103(3):384-386. doi:10.1001/archpedi.1962.02080020396041

The viruses used in this study have been derived from the "Leningrad 4" strain. This human tissue culture passaged measles virus was then adapted to either chick fibroblast or to primary guinea-pig kidney monolayers. After prolonged adaptation, virus grown in these tissues was used to produce the vaccines used. The virus after adaptation to these tissues could no longer multiply in children when administered through the upper respiratory tract or via the conjunctiva; nor did clinical symptoms nor immunity to measles follow.

When administered intradermally or subcutaneously, in a dose of 200-1,000 TC infectious units to healthy children 1 to 6 years of age, this attenuated virus gave rise in 85% of susceptible children to a characteristic vaccinial response. The incubation period had a mean duration of 8 to 9 days with a minimum of 6 to 7. The febrile reaction lasted 1 to 4 days. Mild catarrhal symptoms (rhinitis,

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