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March 1962

Measles Vaccine in Children with Asthma and Tuberculosis

Author Affiliations

C. Henry Kempe, M.D., University of Colorado Medical Center, 4200 E. 9th Ave., Denver 20.; Professor and Chairman, Department of Pediatrics, University of Colorado Medical Center.

Am J Dis Child. 1962;103(3):409. doi:10.1001/archpedi.1962.02080020421049

Active tuberculosis and asthma are known to be made a good deal worse by measles. In a study of some 7,000 children immunized in Denver, a few with active tuberculosis and asthma were included. Six children suffering from very active pulmonary tuberculosis received Edmonston B measles virus, made available by Dr. Enders, without γ-globulin. Four of these children experienced typical unmodified Edmonston measles and showed serologic conversions, while 2 nonreactors were found subsequently to have low-titer neutralizing antibodies.

Among the children with intractable asthma, 6 received similar immunization and 4 experienced clinical responses and serologicconversions. Again 2 were subsequently shown to have low-titer neutralizing antibodies.

Fifty-three additional children suffering from intractable asthma at an institution preferring killed vaccine immunization, all of whom had negative histories for measles, received uneventfully 3 injections each of adjuvant-type killed measles vaccine made available by Dr. Joel Warren. Only 9 of these children failed to

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