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March 1962

Biologics Control of New Viral Vaccines: General Aspects

Author Affiliations

Roderick Murray, M.D., Division of Biologics Standards, National Institutes of Health, Bethesda 14, Md.; Division of Biologics Standards, National Institutes of Health.

Am J Dis Child. 1962;103(3):434-437. doi:10.1001/archpedi.1962.02080020446058

Introduction  It would be impossible to give a detailed discussion of all the elements which go into the present concepts of control and standardization of virus vaccines at this time. This would require a separate series of conferences; however, certain problems and perhaps some examples can be cited to point up the needs in this area which come within the context of the subject of this conference. The presentation of these problems must, therefore, be quite general but perhaps more important in this form. Most of the established principles have been discussed in one form or another during the conference: the development of a strain or strains, demonstration of the possibility of a vaccine, immunogenicity, assessment of the hazards, side-effects, etc. which may be encountered.

Field Trials  Fundamental in the developing modern concept of the control of new virus vaccines is the information available from the socalled field trial. The

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