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March 1962

Measles Virus Growth in Canine Renal Cell Cultures

Author Affiliations

S. J. Musser, M.S., Biological Research Laboratories, Philips Roxane, Inc., St. Joseph, Mo.; Biological Research Laboratories, Philips Roxane, Inc.

Am J Dis Child. 1962;103(3):476-481. doi:10.1001/archpedi.1962.02080020488068

Introduction  The successful isolation and characterization of measles virus in cell cultures of human and simian renal tissue by Enders and Peebles 1 in 1954 was the first sound basis for intensive efforts to develop a practical measles vaccine. An immediate problem, however, was the need for a source of cells capable of supporting adequate growth of the virus, yet suitable for large-scale production of vaccine.In recent years, there have been many reports of the growth of measles virus in various cell culture systems. Thus, the virus has been grown in human amnion2 as well as in rodent renal cell cultures.3 Milovanović et al.4 succeeded in the adaptation of measles virus to the developing chick embryo and Katz et al.,5 by further adaptation, successfully propagated measles in chick embryo tissue cultures. Frankel et al.6 described the use of canine renal cell cultures for the

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