As we progress further into what has been called "the age of cell-cultured biologics," certain prerequisites for human acceptability of the tissue substrates have become of prime importance. In the case of inactivated vaccines, these are:1. The tissue antigen of the virus source should not sensitize man or be reactive in the hypersensitive person. This does not apply so much to the eliciting of antibody alone, but, rather, to the development of sensitization in an appreciable number of people. For example, the repeated administration of many animal proteins, such as those of the chick embryo, while readily able to stimulate humoral antibody, rarely results in the development of hypersensitivity in the recipient.2. The real or hypothetical capacity of the tissue source to be carcinogenic must be considered. This consideration applies particularly to serial cell lines where the occurrence of heteroploidy could conceivably result in a malignant transformation
WARREN J. Simian Cell Cultures for the Manufacture of Measles Vaccines. Am J Dis Child. 1962;103(3):481–484. doi:10.1001/archpedi.1962.02080020493069
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