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March 1962

Measles Serologic Standards

Author Affiliations

Harry M. Meyer, Jr., M.D., Division of Biologies Standards, National Institutes of Health, Bethesda 14, Md.; Division of Biologies Standards, National Institutes of Health.

Am J Dis Child. 1962;103(3):495-502. doi:10.1001/archpedi.1962.02080020507071

Serologic tests for mealses antibodies became feasible in 1954 when Enders and Peebles 1 demonstrated that the virus could be cultivated in monolayers of human kidney cells. These workers promptly applied 2 of the classical procedures of viral immunology, i.e., the complement fixation (CF) and virus neutralization tests. Others 2-4 subsequently contributed to the growing battery of information obtained with these tools. Recently, Periés and Chany 5 observed that erythrocytes from certain primates were agglutinated by fluids containing measles virus. Several groups6-8 have since described hemagglutination and hemagglutination inhibition employing red corpuscles from a number of common monkey species, thus introducing to measles research still another time-tested instrument of the virologist. As is often the case, each investigator has fashioned these serologic procedures to meet the requirements of his particular study with resultant lack of uniformity in methodology.

This paper is concerned with a study of several variables in

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