The development of stable cultures of measles virus, which has lost its pathogenic characters for human beings, is a necessary prerequisite for active immunization against measles with the live vaccine.
There are 3 directions in the investigations on the creation of attenuated strains for the live vaccines:
The adaptation of a measles virus to different species of animals: rabbits, mice, whelp of dogs, monkeys, and suckling pigs.1-4
The adaptation of a measles virus to chick embryos.5,6
The adaptation of a measles virus to cultures of different tissue systems of animals and man, prepared as explants of monolayer cultures.7-11
We have produced an attenuated strain by propagating measles virus, strain USSR-58, isolated in Moscow in 1958, from the blood of measles cases and in parallel studies carried out with cultures of trypsinized tissues of human amnion (HuATC), monkey kidney (MK), or fibroblasts of chick embryos (FEg) in the
ZHDANOV VM, DOSSER EM, FADEEVA LL. Production and Control of Measles Vaccine in the U.S.S.R. Am J Dis Child. 1962;103(3):502–505. doi:10.1001/archpedi.1962.02080020514072
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