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April 1962

Familial Massive Gastrointestinal Bleeding

Author Affiliations

NEW YORK; Philip J. Kozinn, M.D., 141-05 Newport Avenue, Belle Harbor 94, N.Y.; From the Department of Pediatrics and Medicine, Maimonides Hospital, Brooklyn.

Am J Dis Child. 1962;103(4):577-582. doi:10.1001/archpedi.1962.02080020590007

Introduction  Despite intensive investigations as to the etiology of massive bleeding from the digestive tract, a considerable number of cases remain undiagnosed.Even after laparotomy, a definitive diagnosis is not made in approximately 15% of individuals.1,2 Although the outlook is usually good in such instances,2 the literature gives no further diagnostic clues in identifying those subjects whose bleeding is self-limited.The purpose of this communication is to describe 3 patients whose course might give some guidance as to future management of similar situations. These individuals all manifested the following clinical findings.

  1. Onset of repeated episodes of massive bleeding from the digestive tract in the first year of life;

  2. A family history of gastrointestinal bleeding;

  3. Spontaneous cessation of bleeding by the age of 2 years;

  4. Absence of integumentary and vascular abnormalities in other parts of the body.

The 3 children who were affected in this manner are siblings from a family with

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