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June 1962

Late Recurrences of the Nephrotic SyndromeRecurrence After Prolonged Remissions Induced by Adrenal Steroid Therapy

Am J Dis Child. 1962;103(6):794-802. doi:10.1001/archpedi.1962.02080020811009

The ultimate outcome of the nephrotic syndrome in children is a difficult prognostic problem. A favorable response to therapy, with return of clinical and laboratory findings to normal, and maintenance of this state for a prolonged period are generally considered good evidence for a complete remission or cure of the disease. However, occasional patients have recurrences of nephrosis after long periods of well-being. Our experience with 5 such cases has raised some interesting questions regarding the nature of the disease. This report presents 5 children who had the nephrotic syndrome, were well for a year or more, and then manifested the disease again.

Report of Cases  The figure containing pertinent data on each patient should be consulted when reading the case reports.Case 1.—This white male, born on Sept. 11, 1952, was well until August, 1955, when he was noted to have facial edema and ascites. He was admitted to