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August 1962

Open-Heart Surgery: Neurologic Findings and Electroencephalographic Patterns Before, During, and After Open-Heart Surgery (Two-Year Follow-Up)

Author Affiliations

Eva M. Kavan, M.D., Department of Surgery, University of California Medical Center, Los Angeles 24.; Clinical Fellow, United Cerebral Palsy Research and Educational Foundation, 1959-1960 (Dr. Fowler).; From the Departments of Pediatrics, Surgery (Anesthesia), and Medicine (Neurology), University of California Medical Center.

Am J Dis Child. 1962;104(2):131-141. doi:10.1001/archpedi.1962.02080030133005

Introduction  Since the successful development of open-heart surgery, there has been considerable interest concerning the possible risk of cerebral damage during perfusion when oxygenation of the nervous system may be inadequate. It has also been suggested that preexisting neurologic complications might affect surgical success.1,2The effect of cardiopulmonary bypass on the nervous system has been evaluated during all open-heart operations performed at the University of California Medical Center since 1957. Observations on the first 25 patients operated upon during 1957 have been reported.3 In 1959 and 1960, electroencephalograms were obtained on 33 of the patients who had open-heart surgery 2 years previously. The purpose of this paper is to describe the nature of the electroencephalograms taken before, during, and after open-heart surgery in 1957 and 1958 and their relationship to pre- and postoperative neurologic findings.

Method  Open-heart surgery with the use of the cardiopulmonary bypass was performed on

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