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August 1962

Immunofluorescence in Epidemiologic Control of E. Coli Diarrhea: Incidence, Cross-Infections, and Control in a Children's Hospital

Author Affiliations

Research Associate at The Child Research Center of Michigan (Mr. Page); Senior Research Associate at The Child Research Center of Michigan, and Professor of Microbiology at Wayne State University College of Medicine (Dr. Stulberg).; Cyril S. Stulberg, Ph.D., The Child Research Center of Michigan, 660 Frederick St., Detroit 2, Mich.; From The Child Research Center of Michigan and the Children's Hospital of Michigan.

Am J Dis Child. 1962;104(2):149-156. doi:10.1001/archpedi.1962.02080030151007

For over a decade it has been recognized that hospital outbreaks of infantile diarrhea due to enteropathogenic Escherichia coli (EEC) can be potentiated by the introduction of EEC serotypes into a nursery population of susceptible newborn or young infants.1 Nursery epidemics have appeared to follow either 1 of 2 clinical patterns: There may be a smoldering period of varying duration before the outbreak reaches epidemic proportions,2,3 or the outbreak may be explosive with no advance warning.4

Wheeler1 has pointed out that the smoldering period may represent a build-up of environmental contamination in the absence of overt diarrhea in the nursery. Indeed, there have been a number of reports concerning the incidence of EEC in asymptomatic infants which have led to several views regarding the predisposition of such infants to overt diarrhea or their role in potentiating an outbreak.3,5-10 However, studies of incidence of EEC and

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