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August 1962

Chemical Mediators of Acute Allergic Reaction: A Review

Author Affiliations

Mayo Clinic, Rochester, Minn.; Section of Pediatrics, Mayo Clinic and Mayo Foundation.; Aldrich, R. A., in Careers in Pediatrics, Report of Thirty-Sixth Ross Conference on Pediatric Research, edited by R. H. Spitz, Columbus, Ohio, Ross Laboratories, 1960, p. 71.

Am J Dis Child. 1962;104(2):185-197. doi:10.1001/archpedi.1962.02080030187013

Allergic disease continues to constitute a significant part of pediatric practice. Advances in our understanding of the mechanisms of the acute allergic reaction also continue to occur. We must pause at increasingly frequent intervals to survey some of these advances.

The mechanism of the acute allergic reaction as presently conceived and understood has some steps that may be termed "immunologic" and others that may be termed "physiologic" or "pharmacologic." This review is concerned with the latter.

The theoretical concepts of the pathogenesis of the acute allergic reaction and the experimental and clinical work to support them have been evolved and carried out by many investigators from all parts of the world over a period of many years. To review all the information in documentary fashion in a short article is impossible. The accompanying diagram best summarizes the mechanism in the most understandable way. It is a modification of ones previously

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