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September 1962

Pyelonephritis in Infants and Children: Autopsy Experience at the Boston City Hospital, 1933-1960

Author Affiliations

Charles V. Pryles, M.D., Department of Pediatrics, Boston University School of Medicine, 818 Harrison Ave., Boston 18, Mass.; Formerly research fellow in pediatrics, Boston City Hospital and Boston University School of Medicine; presently research fellow in nutrition, Department of Nutrition, School of Public Health, Harvard University (Dr. Neumann).; Associate professor of pediatrics, Boston University School of Medicine; associate visiting physician, Boston City Hospital; visiting physician, Children's Medical Service, Massachusetts General Hospital (Dr. Pryles).; From the Pediatric Service and the Mallory Institute of Pathology, Boston City Hospital, and the Department of Pediatrics, Boston University School of Medicine.

Am J Dis Child. 1962;104(3):215-229. doi:10.1001/archpedi.1962.02080030217003

It is now becoming increasingly evident that pyelonephritis is one of the more common bacterial infections in infants and children leading to serious consequences if uncontrolled. In the chronic form it may cause serious impairment of renal function with resultant growth failure, renal rickets, uremia, hypertension, and death in the older child and young adult.1-3 In the acute phase it may act as a focus for sepsis,4 and often it may be a serious and life-threatening complication of a variety of other conditions. Presently, with refined techniques of bacterial colony counts on urine and urinary tract visualization, the great incidence and prevalence of the disease are being appreciated more and more.5 An increasing number of morbidity studies are being published, but there is still a dearth of autopsy studies with pathologic data available. We thought it would be of value and interest to examine the experience over

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