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September 1962

Corticotropin Production Response to Methopyrapone: Response in Children to Adrenal Blocking Agent Methopyrapone (SU 4885)

Author Affiliations

Ida H. Gans, M.D., Bruce Lyon Memorial Research Laboratory, Children's Hospital of the East Bay, Grove and 51st Streets, Oakland 9, Calif.; From the Department of Pediatrics, University of Minnesota.

Am J Dis Child. 1962;104(3):258-268. doi:10.1001/archpedi.1962.02080030260008

An adrenal blocking agent, methopyrapone ( SU 4885), is a recent addition to the diagnostic armamentarium of the physician interested in pituitary and adrenal function. Although the production of adrenal steroids can be determined both in the resting state and after stimulation, no comparable methods have been generally available for evaluation of pituitary adrenocorticotropin. If the urinary excretion of steroids were to be measured before and during a stressful situation, one can assume that any increase was mediated by endogenously produced corticotropin. An alternative approach would be to lower the level of circulating hydrocortisone and thus use a physiological stimulus to increase corticotropin release. This latter method has been investigated by Liddle et al.1 in 1958 using methopyrapone, an inhibitor of 11-β-hydroxylation of adrenal steroids. Several investigators2-4 have subsequently reported on its use in adults, and recently a few reports have been published regarding its use in children.5-8

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