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November 1962

Transactions of the American Pediatric Society: Seventy-Second Annual Meeting, Atlantic City, May 10-12, 1962

Am J Dis Child. 1962;104(5):457-498. doi:10.1001/archpedi.1962.02080030459004

2. Demonstration of Antipoliovirus Factors in Human Milk Different from Neutralizing or Retarding Antibody.Horace L. Hodes, M.D.; Ruth Berger, M.D.,* and Magda Hevizy, Ph.M.,* Department of Pediatrics, The Mount Sinai Hospital, New York.

When live poliovirus vaccines are fed to newborn infants, multiplication of the viruses in the intestine and consequent establishment of immunity occur much less regularly than is the case with older persons. This effect may be due to antiviral properties in the human colostrum and human and bovine milk which these children ingest. It has been reported that human milk and colostrum contain antiviral substances which cannot be differentiated from poliovirus antibodies present in human serum.

We have studied the antiviral properties of human milk and colostrum by radio-chromatographic methods which have not hitherto been applied to the study of these substances. We have shown that there are antiviral factors in human colostrum and milk

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