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January 1963

Thyroid Gland Function in the Infant Macaque Monkey (Macaca Mulatta): A Quantitative Study

Author Affiliations

Donald E. Pickering, M.D., Oregon Regional Primate Research Center, 505 N.W. 185th Ave., Beaverton, Ore.; John and Mary R. Markle Scholar in Medical Science, 1957-1962; Director, Oregon Regional Primate Research Center, and Professor of Pediatrics, University of Oregon Medical School (Dr. Pickering).; Department of Developmental Biology, Oregon Regional Primate Research Center, Beaverton, and the Pediatric Endocrine-Metabolic Laboratories, University of Oregon Medical School, Portland, Ore.

Am J Dis Child. 1963;105(1):77-80. doi:10.1001/archpedi.1963.02080040079011

Establishment of the normal composition of the thyroid gland of primates with respect to iodinated components is a fundamental prerequisite to investigation and definition of mechanisms of release, transport, tissue distribution, and metabolic influence of thyroid hormone, particularly during fetal life and infancy.

We have previously reported on the chemical and morphological characteristics of the fetal thyroid gland.1 This paper describes the chemical constitution of the thyroid gland during early infancy in mulatta macaque monkeys with respect to iodinated components (monoiodotyrosine, MIT; diiodotyrosine, DIT, and thyroxine, T4) and the uptake and distribution of I131 among them.

Materials and Methods  The infant monkeys used in this study were delivered spontaneously from healthy pregnant animals selected from the breeding colony. Delivery occurred at an average age of 167±4 days after conception. The ages of all infant animals are expressed as the accumulated age in days after conception (conception age).

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