Establishment of the normal composition of the thyroid gland of primates with respect to iodinated components is a fundamental prerequisite to investigation and definition of mechanisms of release, transport, tissue distribution, and metabolic influence of thyroid hormone, particularly during fetal life and infancy.
We have previously reported on the chemical and morphological characteristics of the fetal thyroid gland.1 This paper describes the chemical constitution of the thyroid gland during early infancy in mulatta macaque monkeys with respect to iodinated components (monoiodotyrosine, MIT; diiodotyrosine, DIT, and thyroxine, T4) and the uptake and distribution of I131 among them.
Materials and Methods
The infant monkeys used in this study were delivered spontaneously from healthy pregnant animals selected from the breeding colony. Delivery occurred at an average age of 167±4 days after conception. The ages of all infant animals are expressed as the accumulated age in days after conception (conception age).
PICKERING DE, SETTERGREN KF, KONTAXIS NE. Thyroid Gland Function in the Infant Macaque Monkey (Macaca Mulatta): A Quantitative Study. Am J Dis Child. 1963;105(1):77–80. doi:10.1001/archpedi.1963.02080040079011
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