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February 1963

Studies on Staphylococcal Infections: I. Interrelation of Phage Type and Some Physiological Properties of Staphylococci, with Special Reference to the Muller Factor

Author Affiliations

Nicola M. Tauraso, M.D., Department of Pediatrics, New York University-Bellevue Medical Center, 550 First Ave., New York 16, N.Y.; Research Fellow in Pediatrics, Harvard Medical School and in Medicine, Children's Hospital Medical Center, recipient of a research fellowship from the National Institutes of Health, U.S. Public Health Service (Dr. Tauraso).; From the Department of Pediatrics, Harvard Medical School, and from the House of the Good Samaritan, Children's Hospital Medical Center.

Am J Dis Child. 1963;105(2):164-174. doi:10.1001/archpedi.1963.02080040166007

Considerable data concerning the physiological activities of strains of Staphylococcus aureus have been accumulated1-4; but the exact mechanism by which staphylococci are able to cause disease is still not understood. It is assumed that, in most situations, the pathogenicity of different strains of this group of microorganisms can be correlated with their biochemical activities. Staphylococci are able to produce in vitro, and also in vivo, a variety of substances, many of which at one time or another have been implicated as active principles connected with virulence. These substances vary considerably in antigenicity, and no absolute correlation has been demonstrated between pathogenicity and any one specific factor. However, there is much evidence to show that the more pathogenic strains produce free coagulase, ferment the carbohydrate mannitol. produce phosphatase, and develop pigment. Many of them also produce a variety of toxins, notably: lethal factor, dermonecrotoxin, the classical α-hemolysin, and leukocidin. More

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