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Article
March 1963

Studies of Premature Infants Receiving Oxytetracycline: Controlled Clinical and Laboratory Studies

Author Affiliations

PHILADELPHIA
H. G. Keitel, M.D., Department of Pediatrics, Jefferson Medical College of Philadelphia, 1025 Walnut St., Philadelphia 7, Pa.; From the Department of Pediatrics, Jefferson Medical College.

Am J Dis Child. 1963;105(3):253-255. doi:10.1001/archpedi.1963.02080040255005
Abstract

There had been relatively little interest in neonatal pharmacology until it became apparent that the use of certain antimicrobial agents was associated with disastrous clinical results, particularly in premature infants.1-4 Toxicity has been observed as a result of high blood levels of certain broad spectrum antibiotics and sulfonamides. Since the incidence of serious infections due to Gram-negative organisms is increasing and since tetracyclines are effective agents for treating infections due to many Gram-negative bacilli, it seemed worthwhile ascertaining the blood levels achieved after the intramuscular administration of oxytetracycline to premature infants and to observe the clinical course of these babies carefully.

Assignment to Oxytetracycline  Immediately on admission to the nursery, infants without clinical disturbances and who weighed from 2,000 to 2,500 gm. at birth were assigned in rotation either to receive oxytetracycline* for the first 7 days of life or to serve as controls. Seven and one-half milligrams per

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