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March 1963

Serum Enzymes in Disease: XII. Transaminases, Glycolytic and Oxidative Enzymes in Normal Infants and Children

Author Affiliations

Hyman J. Zimmerman, M.D., Department of Medicine, Chicago Medical School, 2755 W. 15th St., Chicago 8, Ill.; Instructor, Department of Pediatrics, the Chicago Medical School (Dr. Emanuel); Assistant Professor, Department of Medicine, the Chicago Medical School (Dr. West); Professor and Chairman, Department of Medicine, the Chicago Medical School (Dr. Zimmerman).; Departments of Medicine and Pediatrics, the Chicago Medical School, and the Mount Sinai Hospital.

Am J Dis Child. 1963;105(3):261-264. doi:10.1001/archpedi.1963.02080040263007

Serum enzyme levels have been studied extensively in adults,1-3 but there have been relatively few studies in infants and children. It is apparent that the enzyme values in diseases of children can be interpreted only with a knowledge of the normal levels in the age groups in question. There have been reports of levels of glutamic oxalacetic transaminase in cord blood,4-8 in the neonatal period,6-13 and in childhood.13-15 Several studies have dealt with levels of lactic dehydrogenase,16,4,7,11 aldolase,17 malic dehydrogenase,8 and isocitric dehydrogenase 18 in the serum of cord blood, neonatal infants, or children. One systematic attempt to study levels of glutamic oxalacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, and aldolase from cord blood and throughout normal infancy and childhood did not compare the values in these age groups with those of adults.19

In order to establish the normal levels of

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