[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.206.177.17. Please contact the publisher to request reinstatement.
Article
March 1963

Acrodermatitis Enteropathica: Case Report and Review of Literature

Author Affiliations

USN
R. C. Tierney, M.D., Chief, Pediatrics, Loring Air Force Base, Maine.; CDR Andrew M. Margileth, MC, USN, Department of Pediatrics, U.S. Naval Hospital, Chelsea 50, Mass.; Chief, Department of Pediatrics, U.S. Naval Hospital.

Am J Dis Child. 1963;105(3):285-291. doi:10.1001/archpedi.1963.02080040287011
Abstract

In 1942 Danbolt and Closs 1 were the first to describe 2 children with diarrhea, periorificial dermatitis, alopecia, and apathy. Since then 65 cases have been reported, 3 of which were in adults.2-4 Acrodermatitis enteropathica is a rare familial disorder with a recessive mode of transmission. Females are affected more often, and a history of familial occurrence is noted in 60% of the cases. Siblings but no parents have been affected, although consanguinity of the parents was noted in 5 cases. Because of the rarity of this disease our observations in a case and a review of the literature may be of interest to physicians caring for children with this problem.

Report of a Case  The patient, age 4 months, was admitted on Dec. 16, 1959, to Chelsea Naval Hospital because of recurrent dermatitis, diarrhea, and failure to thrive. The infant was well until 5 weeks of age when

×