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April 1963

Neonatal Hepatitis and Its Relation to Viral Hepatitis of Mother: A Review of the Problem

Author Affiliations

K. Aterman, M.D., Woman's Medical College of Pennsylvania, 3300 Henry Ave., Philadelphia 29, Pa.; Professor of Pathology.

Am J Dis Child. 1963;105(4):395-416. doi:10.1001/archpedi.1963.02080040397014

Giant cell hepatitis of infancy (for some of the other terms used for this condition see Fienberg1), one of the causes of jaundice in early life, is a disorder of unknown etiology which has attracted much attention in recent years. It is characterized by the presence, in the liver chiefly of young infants, of varying numbers of multinucleated giant cells of hepatocellular origin and by the absence of any other demonstrable pathological condition which could be held responsible for either the jaundice, when present, or for the development of the characteristic giant cells. This definition, however, probably covers only one, perhaps the most obvious, group of cases, as will be shown later in this paper, since it excludes, on the one hand, those undoubted cases of viral hepatitis in young infants where no giant cells have been seen2-19 and, on the other, certain pathological conditions of the infant's

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